Thomas Renné Selected Research

Bradykinin

11/2019	Design and characterization of α1-antitrypsin variants for treatment of contact system-driven thromboinflammation.
1/2019	Neutrophils engage the kallikrein-kinin system to open up the endothelial barrier in acute inflammation.
12/2017	Cleaved kininogen as a biomarker for bradykinin release in hereditary angioedema.
11/2017	The plasma contact system, a protease cascade at the nexus of inflammation, coagulation and immunity.
1/2017	Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases.
11/2016	Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations.
8/2015	Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III.
4/2015	Plasma contact system activation drives anaphylaxis in severe mast cell-mediated allergic reactions.
3/2013	Hereditary angioedema: a bradykinin-mediated swelling disorder.
12/2009	Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo.

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Thomas Renné Research Topics

Disease

46	Thrombosis (Thrombus) 02/2022 - 07/2005
24	Hemorrhage 02/2022 - 07/2005
17	Inflammation (Inflammations) 01/2022 - 02/2006
9	Myocardial Infarction 01/2021 - 01/2016
9	Edema (Dropsy) 11/2019 - 09/2005
7	Hereditary Angioedemas 11/2019 - 02/2011
5	Neoplasms (Cancer) 03/2022 - 11/2008
5	Infections 01/2022 - 04/2008
5	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 04/2008
5	Pulmonary Embolism 11/2021 - 12/2009
5	Polyps 01/2021 - 12/2009
4	Thrombocytopenia (Thrombopenia) 01/2022 - 11/2015
4	COVID-19 01/2022 - 05/2021
4	Stroke (Strokes) 11/2021 - 03/2006
4	Chest Pain (Chest Pains) 12/2017 - 01/2016
3	Hypertension (High Blood Pressure) 12/2021 - 11/2011
3	Vascular System Injuries 01/2021 - 09/2011
3	Thromboembolism 01/2020 - 07/2005
3	Venous Thrombosis (Deep-Vein Thrombosis) 01/2019 - 04/2011
3	Angioedema 11/2016 - 12/2006
2	Infarction (Infarctions) 11/2021 - 04/2008
2	Carotid Artery Thrombosis 01/2021 - 04/2016
2	Hemophilia A (Haemophilia) 07/2020 - 01/2015
2	Wounds and Injuries (Trauma) 01/2018 - 02/2014
2	Vascular Diseases (Vascular Disease) 02/2017 - 11/2011
2	Anaphylaxis (Anaphylactic Shock) 01/2017 - 04/2015
2	Prostatic Neoplasms (Prostate Cancer) 05/2016 - 09/2015
2	Hereditary Angioedema Type III 08/2015 - 12/2006
2	Hypotension (Low Blood Pressure) 04/2015 - 09/2013
2	Hypersensitivity (Allergy) 09/2013 - 11/2012
2	Brain Infarction 07/2008 - 04/2008
1	Traumatic Brain Injuries (Traumatic Brain Injury) 05/2022
1	Pituitary Neoplasms (Pituitary Adenoma) 03/2022
1	Adenoma (Adenomas) 03/2022
1	Acromegaly 03/2022

Drug/Important Bio-Agent (IBA)

39	Factor XII (Hageman Factor)IBA 01/2022 - 07/2005
18	FibrinIBA 01/2022 - 03/2006
17	Peptide Hydrolases (Proteases)FDA Link 11/2017 - 02/2006
15	PolyphosphatesIBA 11/2021 - 12/2009
12	Biomarkers (Surrogate Marker)IBA 05/2022 - 01/2016
11	Heparin (Liquaemin)FDA LinkGeneric 02/2022 - 04/2008
11	BradykininIBA 11/2019 - 09/2005
10	Thrombin FDA Link 02/2022 - 12/2007
9	Proteins (Proteins, Gene)FDA Link 03/2022 - 08/2005
8	AnticoagulantsIBA 02/2022 - 09/2011
8	Thromboplastin (Tissue Factor)IBA 01/2022 - 11/2010
8	Factor XI (Plasma Thromboplastin Antecedent)IBA 01/2017 - 12/2007
7	Hemostatics (Antihemorrhagics)IBA 02/2022 - 07/2007
7	PolymersIBA 01/2019 - 12/2009
6	TroponinIBA 01/2021 - 01/2017
6	Troponin IIBA 01/2019 - 01/2016
5	Plasma KallikreinIBA 02/2022 - 12/2009
5	High-Molecular-Weight Kininogen (Kininogen, High Molecular Weight)IBA 02/2022 - 09/2008
5	CollagenIBA 01/2022 - 07/2005
5	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 11/2008
4	Peptides (Polypeptides)IBA 01/2022 - 08/2010
4	Complement C1 Inhibitor Protein (C1 Esterase Inhibitor)IBA 11/2019 - 02/2011
4	Small Interfering RNA (siRNA)IBA 01/2019 - 04/2008
4	KininsIBA 02/2011 - 12/2006
4	Bradykinin Receptors (Bradykinin Receptor)IBA 08/2010 - 05/2008
3	CytokinesIBA 01/2022 - 01/2020
3	Testosterone (Sustanon)FDA Link 12/2021 - 10/2018
3	ChemokinesIBA 12/2021 - 08/2013
3	Phosphates (Orthophosphate)IBA 11/2021 - 12/2009
3	Fibrinolysin FDA Link 01/2021 - 11/2016
3	Blood Coagulation Factors (Coagulation Factor)IBA 01/2021 - 09/2011
3	ferric chlorideIBA 01/2021 - 11/2010
3	EnzymesIBA 10/2018 - 04/2016
3	Kininogens (Kininogen)IBA 12/2017 - 12/2009
3	CoagulantsIBA 05/2016 - 07/2009
3	Rose BengalIBA 04/2016 - 04/2008
3	A-factor (Streptomyces)IBA 01/2016 - 02/2014
3	Neutralizing AntibodiesIBA 08/2015 - 02/2014
2	Fibrinolytic Agents (Antithrombotic Agents)IBA 01/2022 - 01/2017
2	Interleukin-17 (Interleukin 17)IBA 01/2022 - 11/2021
2	von Willebrand FactorIBA 01/2022 - 10/2021
2	LipidsIBA 01/2022 - 01/2022
2	VaccinesIBA 12/2021 - 12/2021
2	Deoxyribonucleases (DNase)FDA Link 05/2021 - 12/2017
2	Glycoproteins (Glycoprotein)IBA 01/2017 - 07/2009
2	Serine Proteases (Serine Protease)IBA 01/2017 - 07/2007
2	Polysaccharides (Glycans)IBA 01/2017 - 09/2013
2	Angiotensin IIIBA 01/2017 - 11/2011
2	Factor XIIa (Coagulation Factor XIIa)IBA 04/2016 - 11/2010
2	Enzyme Precursors (Zymogens)IBA 04/2016 - 03/2014
2	AllergensIBA 04/2015 - 02/2011
2	Factor VIIa (Activated Factor VII)IBA 08/2014 - 11/2010
1	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 03/2022
1	OMS 2017IBA 03/2022
1	Hormones (Hormone)IBA 03/2022
1	Growth Hormone (Somatotropin)IBA 03/2022
1	Monoclonal AntibodiesIBA 03/2022
1	somatostatin receptor 2IBA 03/2022
1	Somatostatin Receptors (Somatostatin Receptor)IBA 03/2022
1	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 02/2022
1	CoumarinsIBA 02/2022
1	Amino Acids FDA Link 01/2022

Therapy/Procedure

13	Therapeutics 03/2022 - 07/2005
2	Extracorporeal Membrane Oxygenation 12/2021 - 09/2014
2	Lasers (Laser) 09/2012 - 11/2010